Entresto contains sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin receptor blocker). Sacubitril increases levels of beneficial peptides that support cardiovascular and kidney function, while valsartan blocks the angiotensin II receptor, reducing its effects on blood vessels and aldosterone release.
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Entresto is used to:
Heart Failure
For Adults:
For Pediatric Patients (1 year and older):
- Pregnancy & Lactation: Should not be used due to potential harm to the fetus or nursing infant.
- Pediatric Use: Safe for ages 1 and older; not established for infants under 1 year.
- Elderly Patients: No significant differences in response.
- Liver & Kidney Impairment: Dose adjustments may be required for moderate/severe impairment.
Common side effects include:
Store in a cool and dry place, protect from light. Keep out of reach of children.